Corneal Biomechanics In Patients With Glaucoma: The Effect Of Pupillary Dilatation

\n Aim:  In this study, we aimed to evaluate the effect of pupillary dilatation on intraocular pressure values and corneal biomechanical properties using Ocular response analyzer in eyes with primer open angle glaucoma.

\n Patients and Methods:  Goldmann correlated intraocular pressure, corneal corrected intraocular pressure, corneal hysteresis and corneal resistance factor were all respectively evaluated in 28 eyes of 15 patients with primary open angle glaucoma before and 30 minutes after tropicamide 0.5% instillation.

\n Results: Their mean age was 57.7±13.2 years (range 45–65 years). The mean corneal hysteresis, corneal resistance factor, Goldmann correlated intraocular pressure and corneal corrected intraocular pressure measurements of the eyes were 9.5±2.2 mmHg, 10.1±2.1 mmHg, 16.2±2.8 mmHg, 17.2±3.6 mmHg before tropicamide instillation, and 9.7±2.2 mmHg, 10.1±2.0 mmHg, 16.9±3.5 mmHg, 18.2±4.0 mmHg after tropicamide instillation, respectively. There was statistically significant difference between pre- and post-tropicamide instillation for Goldmann correlated intraocular pressure and corneal corrected intraocular pressure (p=0.043, p=0.015, respectively; paired t-test) while no statistically significant difference was found for corneal hysteresis and corneal resistance factor (p=0.057 p=0.702, respectively; paired t-test ).  

\n Conclusion: Pupillary dilatation with 0.5% tropicamide seems to have a decreasing effect on on intraocular pressure while no effect was noted for corneal biomechanical properties in primer open angle glaucoma patients.

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