Effect Of Geraniol On Brain Cholesterol, Vitamin A And E Levels In The Hydrogen Peroxide-Treated Rats

Aim: Geraniol, a monoterpene, is a plant-derived natural antioxidant. Hydrogen peroxide (H2O2) is a member of reactive oxygen species (ROS). The objective of this study is to de-termine the effect of geraniol on brain cholesterol and lipophilic vitamins such as vitamin A (retinol) and vitamin E (alpha (α)- tocopherol and α-tocopherol acetate) in H2O2-administrated male rats. Materials and Methods: Adult male Wistar rats were randomly divided into four groups (n=7). Geraniol (50 mg/kg) and H2O2 (16 mg/kg) were administered by an intraperitoneal injection for 30 days with a 1-day interval. Brain samples were homogenized and cholesterol, α-tocopherol, α-tocopherol acetate, and retinol levels analyzed from lipid extracts by HPLC. Results: Brain cholesterol level was found to be significantly higher in the H2O2 group than the control group. Brain α-tocopherol acetate levels were found to be significantly higher in the H2O2 and the geraniol+H2O2 groups than the control group. There was no difference in retinol levels between any groups. Conclusion: In conclusion, our results indicate that brain cholesterol and α-tocopherol acetate levels are affected by H2O2-induced oxidative stress. Moreover, we suggest that geraniol has the potential to reduce the effect of H2O2 in male rats.