Evaluation Of The Relationship Between Vitamin D And Hba1c Levels In Diabetic Patients

\nAim: Diabetes is a serious health problem which has increased rapidly in recent years and causes numerous complications. Vitamin D levels may be a contributing factor to the glycemic control. The aim of the study was to evaluate the relationship between vitamin D levels and glycemic control in diabetic patients.

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\nMethods: 330 patients with Diabetes Mellitus type 2, who were admitted to our outpatient clinic between September 2015 and June 2016, were included in the study. Patients were stratified into three groups according to the vitamin D levels; ≤20 ng / mL, between 20-30 ng / mL and ≥30 ng / mL. These groups were compared in terms of patients' socio-demographic characteristics, blood parameters, diabetes-related characteristics, and diabetes treatment. Patients were categorized into two groups according to the HbA1c levels;  ≤7% and  ≥7%. The same parameters and vitamin D values were compared between two groups. All data were recorded into the SPSS version 21. Participants' demographic datas, percentage and frequency values, were tabulated. A p value  of <0.05 was the limit for statistical significance. 

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\nResults: A total of 330 patients (51.2% females, mean age 53,79±10,2 years) with diabetes were interviewed. When evaluated in terms of body mass index, 13.9% (n = 46) were classified as normal, 34.5% (n = 114) were overweight and 51.5% (n = 170) were obese. When patients were divided into groups according to vitamin D levels, 286 (86.7%) patients with a vitamin D level below 20 ng / mL and 44 patients (13.3%) with a level above 20 ng / mL were detected. When patients were compared according to vitamin D levels, there was a negative correlation (-r = 0.357, p <0.001, -r = 0.344, p <0.001, respectively) between vitamin D levels and patients' fasting blood glucose level (FBG) and postprandial glucose level (PBG). There was a negative correlation (-r = 0.433, p <0.001) between vitamin D levels and HbA1c levels. Negative correlation (-r = 0.131, p <0.05) was found between vitamin D and triglyceride levels.

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\nConclusion: Vitamin D levels were significantly lower in patients with HbA1c> 7% (n = 191) when compared to those with HbA1c <7 (n = 95) (p <0.001). Vitamin D levels may be important in glycemic control of diabetic patients.