Fatal Anaphylactic Reaction Following The First Dose Administration Of Ceftriaxone

Fatal anaphylactic reaction due to ceftriaxone is quite rare. Taking into consideration that cephalosporins may also cross-react with beta-lactam antibiotics, the risk of allergic reactions in patients using cephalosporins for serious reasons should not be disregarded. Here, we present a patient with fatal anaphylactic reaction following the first dose administration of ceftriaxone who had been followed in our clinic for liver cirrhosis due to hepatitis C (HCV) and was hospitalized for pneumonia. Detailed allergy history including betalactam antibiotic allergy should carefully be questioned in patients to whom cephalosporin treatment is planned. Even in the first dose of administration, caution should be taken and drug administration should be performed after appropriate measures.