The Effect of Pinaverium on Isolated Guinea-Pig and Rabbit Stomach Fundus Contracted With Acetylcholine and Its Relation With Calcium

ESRA KISMET ATALIK, H. İbrahim Karabacak, Ekrem Çiçek

  • Year : 1995
  • Vol : 11
  • No : 1
  •  Page : 65-68
In this in vitro study, by using Ca-I-2 -free me-dium, the effect of pinaverium on acetylcholine (ACh) responses induced by cumulative addition. of Ca+2 (10-4 - 10-2 M) was investigated in isolated gu-inea pig and rabbit stomach fimdus. The responses induced with 104 M ACh, Ca+2 -free medium containing 0.77 mM Na7 EDTA, sho-wed a dose-dependent and significant increase by addition of cumulative concentration of Cal-2 . In the presence of pinaverium (10-5M), the maximum response decreased significantly in both pre-parations. It was showed that the inhibition induced by pinaverium was higher in guinea-pig stomach fundus than in rabbit stomach ftmdus (P<0.05). The results suggest that extracellular Ca+2 - int-lux can be inhibited by pinaverium in both pre-parations.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
The Effect of Pinaverium on Isolated Guinea-Pig and Rabbit Stomach Fundus Contracted With Acetylcholine and Its Relation With Calcium
, Vol. 11 (1)
Received : 15.10.1995, Accepted : 15.10.1995, Published Online : 15.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;