Reprogramming Regulatory T Cells To Promote Tolerance İn Allergic Diseases

Reprogramming Regulatory T cells to Promote Tolerance in Allergic DiseasesTalal Chatila,Amir Massoud

  •  Yıl : 2019
  •  Cilt : 35
  •  Sayı : 1
  •  Sayfa : 69-76
Özeti

Allergic diseases are highly prevalent disorders that exact a heavy toll of morbidity. Whereas a fine balance is normally struck between immune effector and tolerogenic mechanisms to ensure effective but self-contained and minimally damaging immune responses, this balance fails in those disorders. Of particular interest is the role in these disorders of regulatory T (Treg) cells, which act to maintain immune homeostasis and ward off exuberant or tissue damaging immune responses. In this review, we explore how chronic allergic inflammation can destabilize Treg cells and promote their acquisition of pathogenic T helper cell phenotypes that aggravate disease. We describe cellular and molecular mechanisms involved in such re-programming of Treg cells and therapeutic opportunities by which reprogramming can be reversed to reestablish enduring tolerance.

  • Çıkar İlişkisi

Yazışma Adresi : Talal Chatila, Boston Children’s Hospital, Harvard University Division of Immunology-Allergy-Rheumatology
Eposta : amirmassoud@gmail.com
Atıf yapmak için : Massoud A, Chatila T. Reprogramming Regulatory T Cells to Promote Tolerance in Allergic Diseases. Selcuk Med J 2019;35(1): 69-76

Açıklama : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.

Reprogramming Regulatory T Cells To Promote Tolerance İn Allergic Diseases, Derleme,
, Vol. 35(1)
Geliş Tarihi : 15.10.2018, Kabul Tarihi : 04.03.2019
Selçuk Tıp Dergisi
ISSN: 1017-6616 ;
E-ISSN: 2149-8059 ;
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