Selçuk Tıp Dergisi Arşiv

Phenylephrine, clonidine and potassium chloride (KCL) were used as contractive agents in this in vitro study conducted in the canine vena portal, and prazosin, yohimbine and hydralizine were tested to inhibit the contractions due to the specified drugs. Phenylephrine and clonidine administered in cumulative concentrations produced dose-dependent contractions and these responses were inhibited noncompetitively by prazosin (10-6M) and yohimbine (10-8M, 10-6M). KC1 (80 mM) caused a topical and phasic contraction, this response was reduced by hydralazine given at ktimllative concentration. The findings suggest that alpha1 and alpha2 - adrenergic receptor antagonists and direct acting vasodilator drugs can be used to eliminate vena porta vasoconstriction.

In this in vitro study performed in the rat gastro-esophageal sphincter, the relaxing effects of verapamil, nifedipine and nitrendipine, which are Ca2 + channel blockers, on contractions due to carbachol were investigated. When the% relaxations obtained with the said antagonists were compared, it was seen that verapamil and nitrendipine relaxed at the same rate, whereas the relaxation achieved with nitrendipine was lower than the other two drugs.

It is known that metizerjid inhibits 5-HT contractions and is also a partial agonist in studies conducted on many tissues. In the present study, the contractions caused by 5-HT (Serotonin) were inhibited by 10-11 and 10-10 M. mianserin and similarly by 10-8 and 10-6 M. metizerjitis in a dose-dependent and non-competitive manner. In addition, the maximum contraction response generated by metizerjid applied in cumulative concentration was also significantly reduced by mianserin. In the studies performed, the intrinsic activity of metizerjid was 0.3 0.04. As a result, in isolated calf coronary artery, it has been shown that metizerjid is a partial agonist, its effect is probably through 5-HT receptors and mianserin is effective in this tissue even in very small doses.

Although many studies have been conducted on electrolytes in blood serum, we could not find a study with total ion concentration in the literature. In order to show that the total ion concentration in blood serum can be determined using radiofrequency electromagnetic field, we found the average of the total ion concentrations as 290 m mol / L from the 5 cc blood samples we obtained from 40 healthy people aged between 17 and 40 years. We determined the average of the total ion concentrations of 730 m mol / L and the average of the urine total ion concentration / blood serum total ion concentration ratio to be 2,537 from the urine of 35 of these 40 people simultaneously.

In this study, a modified embolic cerebral ischemia model using homologous blood clot as embolizing agent in rabbits is presented. In the study in which 16 rabbits were used, homologous blood clot was injected into the right carotid cournirdsarteri. In all rabbits, the fundus of the eye was examined intermittently before and after embolization, and carotid angiography was performed in four of them to monitor the progression of the embolism. The brains of rabbits killed by giving intracardiac formaldehyde 24 hours after embolization were removed and the localizations and volumes of the infarct sites were determined in serial sections.

Acrocentric chromosome associations obtained from the cord blood of 10 healthy newborns in the presence of Bromodeoxyuridine (BrdU) at various times were examined and the values ​​were compared with the values ​​in cells without BrdU. As a result, significant differences were seen between Satellite Association with and without BrdU added. When classified according to the association types observed in some cells in the presence of BrdU, it was observed that neither BrdU nor the association type had an effect on the frequency of satellite association. In the presence of BrdU, no evidence could be obtained that the chromatids behave in an unintentional way in the parent cells and in the acrocentric chromosomes in association.

In the 1984-1985 academic year, among 4065 students who were randomly selected from primary school children in Diyarbakır city center with a systematic sampling rate of 10%, the rate of rheumatic fever by using a questionnaire was found to be 9.1%. This rate is higher than the rates found in studies conducted in other regions of our country. When the anamnesis of these children were deepened retrospectively, the fact that at the time of diagnosis, most of the children had only extremity pain and no examination was performed, it was thought that some of these pains may have occurred due to reasons other than rheumatic fever. Because of the retrospective diagnosis, the rate of major findings was lower than that reported in the literature. The distribution of patients with rheumatic fever history and valvular lesions by gender did not show a significant difference in accordance with the literature. The distribution of children with valve damage by age has increased gradually in accordance with the literature. Valvule lesion was found in 1.2% in our study. These values ​​are lower than the values ​​reported from Iran, but higher than the values ​​reported in other developing countries and in our country. In the examination of valvule lesions, it was observed that, in accordance with the data in the literature, the most frequent mitral valve involvement was followed by aortic valve involvement. Again, in accordance with the literature, the most common type of valve lesion was mitral insufficiency. Unlike the difference reported in the literature, both mitral and aortic involvement did not differ significantly according to gender. In the retrospective examination of the anamnesis of the cases with valve involvement, no complaints were found by reducing rheumatic fever in 37.2% of the cases. This situation was attributed to the symptoms being mild and forgotten or the occurrence of carditis without other major findings.

In this work we searched tinnitus prevalance and personality charecteristics of tinnitus sufferers. Tinnitus prevalance was found 20.13 % in the adult population. This result is not different in the tinnitus literature.

Tinnitus has many causes and is still a diagnostical and therapeutical problem in the field of Oto-Laryngology.In this article a new diagnostical and therapeutical method was presented in tinnitus that was different from the other known diagnostical and therapeutical ones. The results, especially, obtained from idiopathic tinnitus were discussed.

Hipospadias is a condition which the opening of the urethra is on the ventral surface penis from corona of glans to the perineum. The opening of the meatus in this congenital anomaly was 70 percent on the distal part of the penis ventral surface. To relief this anomaly surgically there are two methods, first is Beck-Hacker is recently modified by Baran and the other was Bevan's which used older.

The only and main source in blood donation is human. It is imperative to evaluate the factors related to blood donors well to obtain the blood continuously and freshly. In this study conducted in Konya, the desire of one person to donate blood to another person was found to be significantly higher in youth and men. In addition, the education levels of the individuals affected voluntary blood donation. The behavior of participating in this social event was higher in experienced people (p <0.01).

In a diabetic person, foot malformations frequently occur due to neuropathy, infection and vascular disorders. Radiographic destruction of bones was detected in 16 of 70 diabetic patients (10 type 1.60 type II). In 7 of these 16 patients, erythema, ulceration and gangrenous lesions were detected on the skin of the feet. Radiological destruction of the foot bones was demonstrated in 9 of 55 diabetic patients without skin lesions and gangrene. No relationship could be established between the duration of diabetes and the patient's age and foot lesions. Heart failure is the most important factor that accelerates skin lesions. Also, poor foot hygiene provokes the event. Therefore, in order to prevent complications that may occur in the diabetic foot, it is necessary to keep the patient away from foot care and provoking factors.

An increase in serum gastrin levels is noted in patients with chronic renal failure. In our study, serum gastrin levels of 24 patients with chronic renal failure who were under 10 conservative treatment and 14 hemodialysis treatment were determined. Serum gastrin levels of both groups were significantly higher than the control group (p <0.05). There was no correlation between total gastrin levels and serum creatinine levels. In addition, we found that serum gastrin levels after hemodialysis did not show a significant decrease compared to pre-hemodialysis.

Magnesium (Mg2 +) deficiency is likely to occur when acute myocardial infarction develops in patients with ischemic cardiomyopathy, diabetics, hypertensive patients treated with diuretics and diuretics. Potassium (K) deficiency may accompany Mg2 + deficiency. In 37 patients with acute myocardial infarction (AMI), serum K + and Mg2 + analyzes were performed and in 3 of 7 patients with hypomagnesemia, ventricular rhythm disturbances were detected (42.8%). In the group of 30 people with serum Mg2 + levels within normal limits, ventricular arrhythmia was detected in 4 (13.3%) patients.

Insulin receptor binding and levels on circulating lymphocytes in 13 healthy children. Their ages were changing between 9-17 years. The insülin binding rate(insulin receptor level) was found between 9,10 percent and 11,81 percent. The finding results were higher than in adults.

62 isolated KleLsiella strains were cultivated from urine, stool, upper respiratory tract specimens (throat, phlegm), bile, skin lesions and blood specimens. In result of bioche-mical tests, 49(79,3%) of 62 strains were Kl. pneumoniae, 9(14,53%) Kl. ozaenae, 2(3,22%) KI. rhinoscleromatis. Two Klebsiella strains were not determined. In serological determination of 40 Klebsiella species type 2 have been found more than others.

Surgical treatment was performed in 21 hips of 18 children aged 5-11 years with congenital hip dislocation. Open reduction, Salter or triple osteotomy and femoral osteotomies were performed. The patients, 15 girls and three boys, were followed for at least one year. It was evaluated radiologically according to the Severin classification and 19 hips (90%) were found to be very good and good, and two hips (10%) bad. Re-dislocations occurred in two hips and one of them developed avascular necrosis of the femoral head.

Five anatomical internal fixation devices with intertrochanteric femur fractures were reviewed. It was our patients. The most was 12%. They were followed up for a mean age of 48 years 61.2 less than 3 months, average 18 months. In our evaluation, it was seen that there were more complications in unstable fractures and 92% of the patients gained their prefracture conditions.

Conventional bitermal caloric test was done in the 28 patients who hac not any complaints about vertigo and any other vestibular findings. Slow phase maximum velocities of caloric induced nistagmus were measured and statistically evaluated. Vestibular hipofunction was notable in the diabetics. This result suggested that vestibular subclinical disfunction was cronically developed in the diabetics and this condition allowed to compansate it. So these patients might be free from the complaint of vertigo.

Vestibular examination was performed on 47 amateur boxers with a test battery including neurological, electroencephalographic and minimal balance tests. Dysrhythmia was observed on electroencephalography (EEG) in 38.29% of the patients in whom no neurological finding could be obtained at clinical level. This finding was consistent with the literature information. Vestibular tests showed signs of decreased vestibular sensitivity, which was evident in the right labyrinth. These findings were discussed with the literature on biomechanics of chronic traumatic encephalopathy syndrome (fist drunkenness). It was concluded that vestibular tests may be important for the detection of this syndrome at a subclinical level and for early warning.

By using clinical and electrophysiological data, this study was carried out to detect the rate of peripheral neuropathy caused by diphenylhydantoine in 31 epileptic patients.It was seen that subclinical polineuropathy at least, might occured in the patients who had been taking the drug for a short period, such as 2 years time. Pathogenesis of polineuropathy was discussed in the light of the relevant literature.

Preliminary diagnoses of 118 patients who applied to our cytogenetics laboratory between 1.1.1988 - 31.1.1989 and the results of the cytogenetic findings were evaluated with the clinic they were sent to. Of the 118 cases examined, 21 of them had Mongolism, 1 of them had Turner syndrome, 3 of them had sexual development disorders, and 2 of them had karyotypic findings suitable for Fanconi Aplastic Anemia. The role of the cytogenetics laboratory in the diagnosis of diseases with chromosomal disorders and the prevalence of these diseases are discussed in the light of the literature.

Twenty newborn bables from healthy mothers were examined for Sister Chromatid Exchane (SCE) rates. Among the twenty newborns ten were male and the remaining were females. Sister chromatid exchange rate was 7.03 for female infants where this rate was 7.20 for male infants.However these differ'ences were statistically insignificant (p > 0.05). These findings were compared and discussed with these ratios that were found previc,usly for different age and sex groups of older ages.

Clinical, hematologic and cytogenetic findings of two cases were invastigated. One of them was Fanconi's aplastic anemia and other one was Acute Myeloblastic Leukemia associated with Fanconi's aplastic anemia. Chromosomal abnor-malities of these cases and the possible effects of these abnormalities on the progress of the disease and malignancy were ciscussed.

Trichoepithelioma is a ra•e antity. Trichoepithelioma together with myasthenia gravis and alopecia has been reported here.No trichoepithelioma cases were reported in the literature that occur together with growth retardation and Medullablastoma.

Fistula of parotid gland is usually found rarely. The majority of cases occur by the injuries following a surgical intervention and the past history of the infection in the lodge region of parotid. In this article, a patient with an over discharge especialiy when he is eating from the opening of his fistula in the left retroauricular area is presented. The patient was succestWay treated.

Superior Mesenteric Artery Syndrome (SMAS), is a rare clinical case. In this article, a-20-year old man with SMAS is reported and showed laparotomies associated with a long history of repeated vomiting and weight losses. After resuscitation, he was treated surgically and subsequently recovered well. In this paper the diagnostic difficulties of SMAS were discussed.