Selçuk Tıp Dergisi Arşiv

İn this study, we investigated the relationships betvveen tumour proliferating determinants (PCNA, Ki-67, and index of AgNOR) in infiltrating ductal carcinoma of breast both oestrogen receptor protein and P53. Twenty-five cases vvhose were operated and diagnosed as infiltrating ductal carcinoma were included in the study. The tu­ mour containing slides were stained immunohistochemically with PCNA, Ki-67, estrogen receptor protein and P53. One thousand cells were counted and the indexes for each staining were established as the number of po- sitive cells was divided to 1000. Additionally, the NOR corpuscles which were established by silver impregnation technique in 100 tumour cells were counted and the AgNOR index was determined by dividing this count to 100. AH indexes were compared to each other by statistical means. VVe found that oestrogen receptor positiviness was negatively linked to the expression of P53 and the indexes of PCNA, Ki-67, and AgNOR. İn conclusion, we de- monstrated that ali of above mentioned indexes had close relationships to each other, so they may have prog- nostic values.

İn thls study, vve aimed to determine the effects of zinc deficiency on some hormonal parameters in rats. The in- vestigation was carried out on subjects which vvere 6-week-old Spraque Dawley rats. The first group of rats (n=9) vvere fed with a diet lack of zinc for 3 vveeks (n=10). The second group got a normal diet as Controls (n=10). At the end of three vveeks, zinc, grovvth hormone, free and total T3 and T4, TSH, free and total testosterone levels vvere determined in sera. On the vvhole, the data evaluated in the study indicated that zinc deficiency for 3 vveeks did not cause to any significant alteration in grovvth hormone and total T4 levels.. Hovvever, there vvas significant decline in free and total T3, free T4, TSH, free and total testosterone.

The effects of zinc addition to the fluconazole therapy which is a systemic anticandidial agent vvidely used in vul­ vovaginal candidiasis were investigated. Sixty-eight non-pregnant vvomen having sımptoms of vulvovaginal can­ didiasis were evaluated and compared in randomly selected two groups. One of the groups was treated with flu­ conazole (n=33) while the other was treated vvith fluconazole + zinc (n=35). KOH preparation and culture results and relapse ratios vvere compared betvveen two groups. Relaps ratio was found significantly lovver in fluconasole + zinc treated group.

Anthropometric measurements were perform ed to assess the physical growth and developmet of the prim ary school children. For this purpose; the body height and vveight, and head, thorax, ab­ domen, pelvis, upper and lover extrem ities related parts measurements of 356 prim ary school children were com plated and analysed statistically regarding sex and age. The results were also com pared with other studies from different part of the Turkey and possible factors vvhich might have contributed to the differences were discussed. We expect that our findings could be used a reference norm for grovvth and development in Konya and will be useful in the es- tablishm ent of the standart values of Turkish children body measurements.

The aim of this study was to examine vvhether low birth weight has a relation with the physical values of foot size among nevvborns. This study was performed on 60 lovv birth vveight nevvborn infants (30 males and 30 females) and 60 normal healty nevvborns (30 males and 30 females). Bimalleolus vvidth, heel vvidth, food length and food vvidth measurements vvere evaluated. The values of ali parameters excluding heel vvidth shovved statistically sig- nificant relationship with the vveight of nevvborns (p<0.001). There is statistically significant differences foot length and heel vvidth betvveen sexes in low birth vveight of nevvborns, that it was larger from females (p<0.05). Similarly there was also statistically significant differences betvveen sexes of birth groups (p<0.001). Excluding heel vvidth a significant correlation exists betvveen birth vveight and foot measurement parameters of both groups (p<0.001). İt is concluded that measured values of foot parameters are good predictor of lovv birth vveight of nevvborns.

Reports have shovvn opposing results for proposed associations betvveen left-handedness and allergic diseases. İn this study we compared the distribution of right- and left-handers in a group of allergic patients and a control population with a Similiarsex and age distribution. The study (59 asthma, 50 rhinitis, 41 asthma+rhinitis; total 150 patients) and control (81 hospital personels and patients' relatives) groups were given a questionnaire that inc- luded a modified version of the Oldfield's Edinburgh Handedness Inventory. The frequency of left-handedness (LS<0) in the study and control population were 10.7%, 9.9%, respectively and there was no difference betvveen two groups, statistically. The percentage of left-handers was 10.7 % in males and 9.4 % in females for the control group and 11.3 % and 10.3 % in males and females, respectively, in the study group. The distribution of han­ dedness was similiar in two sexes, vvithin the control and patient groups. Allergic patients were divided into two groups according to IgE-mediated (n=114) or non-lgE mediated (n=36). The percentage of left/handers in IgE me- diated and non-lgE mediated vvere 10.5%, 12%, respectively. There was no difference in the incidence of left- handedness among these two groups. There was also no difference in the percentage of left-handers in the al­ lergic asthma (8.5%), allergic rhinitis (% 11.1) and allergic asthma+rhinitis (12.2%) patients. As a result, There was no significant association determined betvveen the groups of allergic asthma/ rhinitis and control groups as the incidence of hand preference.

14.941 patients applied for the Emergency Service of Department of the Medical Faculty of the Selçuk University betvveen 1st January 1998 and 31 st December 1998 Infection diseases were the most common problem, ac- counting 23% of ali upper respiratory infection diseases and accounted 48.4% of ali infection diseases. 52% percent of the children admitted to the emergency service were real cases and 11% percent of the children vvere those who vvere supposed to be real cases and 37 % percent the children vvere not real cases. Patients vvere mostly admitted to the emergency clinic in winter, especially in January and betvveen 8 a.m. and 4 p.m. According to their age levels, They were mostly betvveen at the age level of 5-12 years. If Emergency Medicine Services can be well organised and extended in our country vvhose half of population is children, the Standard of quality in the Units of Children Emergency will be increased.

236 (5.2%)nosocomial infections were detected in 4468 patients hospitalised in our newborn unit in Medical Fa- culty, Selçuk University between 1992 and 1996. 169 (71.6 %) of the infections detected were in prematüre ba- bies while 67 (28.4%) of them in mature babies and that numbers corresponded 11.5 percent and 2.2 res- pectively. The most common infection was sepsis (73.1%) and others such as menengitis (19.3%), pneumonia (3.4%) and others (4.2%) followed it. At least one microorganism growed in 32 (13.5%)specimens obtained from various body fluids. 9 (28.1%) of the miroorganisms were Klebsiella spp. and 8 (25.0%) of were E.coli Mortality rates of the infections were 87.5% for pneumonia, 61.5% for sepsis, 8.7% for menengitis and 60.0% for others, which corresponded an average mortality rate of 51.6 %.

Presently there are many surgical approaches in the treatment of pituitary gland tumors. Among these, trans- nasal- transseptal approach gives the surgeon a good point of view and the opportunity the reach the tumor in a short time. The patient operated by these techniques have been evaluated from the point of rhinologial findings. By discustion the results in the light of literatüre, this approach has been found an acceptable surgical technique for the patient from the anatomic and functional point of view.

Vesicovaginal fistula cases treated in our clinic betvveen 1983-1998 has been evaluated retrospectively. Etiologic causes and approaches to treatment have been discussed. 70.6 % of the cases were caused by gynecologic re- asons vvhereas the remaining 29.4 % were due to obstetric reasons. Three cases treated by electrocoagulation, eleven cases by transabdominal-transvesical approach and another three by transvaginal approach. After eva- luation of the results, 66.6% (2/3) success rate has been reached with electrocoagulation while this rate was 100% (3/3) at transvaginal methods and 72.7% (8/11) with transabdominal-transvesical approach. Three cases which failed at the first application of transabdominal-transvesical method ended up with recovery after the se- cond treatment with the same method. Although the number of cases are not enough to give a solid decision, we concluded that the transvaginal approach may be preferred as a first method in vesicovaginal fistula by con- sidering the lesser amount of morbidity, minimum blood loss, easiness of operation and control över the operated area, shorter hospital stay and simultaneous treatment of stress incontinance.

Concha bullosa is a common anatomical variant of intranasal anatomy. Eighty-six patients who had paranasal sinüs infection were evaluated with CT for lateral nasal wall variations. İt was found that 22 % of the patients had concha bullosa at least on one side. İt was seen that paranasal sinüs infections developed vvithout concha bul­ losa and on the other hand, 15 patient that operated endoscopic surgery was shovvn that this prosedüre is useful for the treatment of sinusitis in cases with concha bullosa.