Selçuk Tıp Dergisi Arşiv

The aim of this in vitro study was to investigate the inhibitory effects of K+ channel blockers, tetraethylammonium (TEA) and glibenclamide, on the isoprenaline-, salbutamol-, theophylline- and aminophylline- induced relaxation in the rabbit trachea. İn the tracheal strlps pre-contracted with carbachol (W 3 M), isoprenaline (10~9 -10~4 M), salbutamol (3x10 '7-10'3 M), theophylline (10'9 -10~4 M) and aminophylline (10'9 -10~4 M) each produced concentration- dependent relaxation. Mean maximal relaxant responses to isoprenaline, salbutamol, theophylline and aminophylline in the tracheal strips vvere 87.83 ± 2.89 %, 75.83 ± 2.04 %, 73.33 ±2.55% and 69.83 ± 2.36 %, respectively. Relaxant responses of these agents vvere significantly inhibited by K+ channel blockers, TEA (W 4 M) and glibenclamide (W 6 M). The inhibitory ef­ fects of K+ channel blockers on teophylline- and aminophylllne-induced relaxations vvere lovver than those of isop­ renaline and salbutamol. The rank order of potency of these compounds was isoprenaline > aminophylline > te­ ophylline > salbutamol and K+ channel blockers caused a displacement to the right of the dose response curves to these agents. Results indicate that the K^ channels play an important role in the relaxant effects of B-adrenoceptor agonists me­ an vvhile their role in the teophylline- and aminophylline- induced relaxation is less.

Electrical stimulation of the supraorbital nerve on one side evokes early reflex contraction of the orbicularis oculi muscle ipsilaterally (R1) and late reflexes bilaterally (direct-R2 and consensual-R2c). The Central pathway of the R1 may conduct through the pons but the exact Central pathvvay of the R2 is not entirely understood. İt has been presumed that the stimulus goes up to the opposite thalamus and/or cortex, than project down to bilateral facial nuclei. İn this study, the blink reflex was investigated in 13 patients with thalamic hemorrhage and in 12 normal subjects. R1 was normal on both side stimulation but R2 and R2c obtained by stimulation on the paretic side slo- wer in latency compared with responses of the non paretic side and the values of the normal subjects. İt is pre­ sumed that the thalamus may modulate the second component of the blink reflex.

The effectiveness of ultrasonography which is used for routine determination of postvoiding residual urine volüme was compared vvith transurethral catheterization. İn 58 male patients who had prostate disease and bladder emp- tying difficulty, pre-postvoiding bladder volumes vvere measured ultrasonographically using Simpson’s method (iti 6 x W x D x H). After ultrasonographic examination, residual urine volüme was determined by postvoiding 10F catheterization. Postvoid residual bladder urine volumes measured by ultrasonography and transurethral cat­ heterization vvere between 0-367 mİ (mean 62.2) and 0-500 mİ (mean 70.7) respectively. A high correlation was demostrated betvveen the catheterized volüme and ultrasound estimation. There was no statistically significant dif- ference betvveen them. Ultrasonography is a noninvasive. practical method vvithout a complication risk and an ef- fective method to evaluate bladder and prostate morphology. Catheterization has risk of urinary infection and urethral stricture secondary to the procedure, also this is an invasive method. l/Ve think that bladder ult­ rasonography techniçue, vvhich does not carry the risk of urinary tract infection or trauma must be preferred in ac- curate determination of postvoiding residual urine volüme.

n determination the ethiology of subarachnoid haemorrhage some radiological diagnostic methods are used. Su- barachnoid haemorrhage, intracranial haemotoma and intravetricular bleeding can be correctly detected by com- puted tomography (CT), but in demostration of small aneurysm or trombosed aneurysm CT can be insufficient. Angiography which is an invasive examination also effective in the diagnosis of intracranial aneurysms and de­ termination of surgical strategy. 98 patients (45 M, 53 F) who have been admitted the hospital because of their acute neurological findings have intracranial aneurysms which were shown by angiography. Ali of these patients have been examined by CT also before angiography. 96 of 98 patients (97.9%) had subarachnoid haemorrhage and in 98 patients there were 103 aneurysms. Only 24 of 103 (23.3%) aneurysms were shown by CT exa- mination. We think that in patients with intracranial haemorrhage which are shown by CT examination, con- ventional angiography or digital substraction angiography remains the gold standart for detailed aneurysms de- tection and also for surgical planning.

Objective : Relation betvveen progression of spontaneous labor and success of induction with serum levels of DHEAS in mother and cord blood. Material-Method : This study contains 140 pregnant women who were follovved and gave birth in our clinic betvveen September 1998-March 1999 gestational age 38-44 vveeks. Blood samples was collected from mothers in latent phase of labor and from umblical cord in labor, serum DHEAS levels were evaluated. Findings : 70 pregnant vvomen vvho were entered and progressed labor spontaneously; and 70 vvomen in whom labor induction was used, vvere compared in terms of cord blood serum DHEAS levels. No statistically important difference was found. But, statistically, mother's serum DHEAS level vvas significantly higher in first group Women vvho entered labor spon­ taneously, 40 of them gave birth in less then 9 hours and 30 of them labor prolayed more than 9 hours. There is no sta­ tistically important difference vvas found in terms of mother and cord blood serum. DHEAS levels. From 70 vvomen in whom labor induction vvas used, in 40 of them induction vvas successful and in 30 of them there vvas no ansvver to in­ duction. There vvas no statistically important defference in therms of mother and cord blood serum DHEAS levels bet­ vveen these two groups. Conclucion : There can be relation betvveen the level of mother's serum DHEAS and the be- ginning of labor. But vve could not find any relation betvveen labor time and the level of cord ant mother serum DHEAS.

This study was performed in the deparment of general surgery of Ankara Universitiy Medical Faculty, betvveen September 1992-December 1992. Thirty patients were diagnosed chronic venous insufficiency and 15 healty per- son were evaluated by colour doppler ultrasonography and the results were compared with venography findings. İn the diagnosis of chronic venous insufficiency, colour doppler shovved 87 % sensitivity, 80 % spesifity, 85 % ac- curacy, % 80 pozitive predictive value, % 87 negatif predictive value, As a conclusion in the diagnosis of chronic venous insufficiency coloured doopler USG can be considered as the primary diagnostic method. İt is also a cheep and non in vasi ve scanning method.

Aim : İn this study vve aimed at determining the prognostic factors and some risk factors in perforating eye in­ juries which have important role in preventable blindness. Method: VVe retrospectively evaluated data from a total of 157 patients, admitted to Fırat University Medical School, Department of Ophthalmology with perforated eye injuries, betvveen 1994-1999. One or two surgical interventions were performed in ali cases. They were eva­ luated with respect to patients’ age, sex and occupation; etiology of trauma, affected tissue, accompanying pat- hological findings, performed surgical intervention, delay betvveen the injury and surgery, Vision level before and after surgery and complication. Result: Of the total 157patients included in this study, 77.7% was male; 22.3 % female; and mean age of patients was 25.25 (4-85) years old. Perforated eye injuries vvere frequently seen (40.1%) in young patients (0-12 years old). This ratio was found to be 19.1% in vvorkers and 15.3 % in farmers. Among the most frequently injured tissues, cornea vvas the first (62.4%) and knives and Sharp tools were res- ponsible from most of the perforations (22.9%). Of the cases 76% vvas received surgical intervention in the first 24 hours' period. Before operation, visual level frequently found to be betvveen perception and projection (15.9). Most frequent complication among the follovv up period vvas ubnormal shaped pupil (29%) and corneal leukoma (25.9%). Conclusion: İt is knovvn that in perforated eye injury treatments, prevention of injuries is more important th an cure. Therefore prevention al public health Services ar e essential. Our results suggest that, urg en t admission to the hospital and possible early surgical intervention is important determinants of visual prognosis after per­ forated eye injuries.

İn this study a revievv of 9 arteriovenous malformation eases surgically treated between October 1991 and Oc- tober 1999 is presented. Of these cerebral AVM cases, 5 were presented with intracranial hemorrhages, 2 had Progressive neurologic deficit, 2 had headaches initially. Surgical mortality was 1/9 in the series. The clinical di- agnostic and therapeutic aspects of cerebral AVM' s ar e emphasized and the literatüre on this subject has been reviewed.

Primary angiosarcoma of breast is a rarely seen tumor type. İt considered that tumor is developing from the pe- rilobular capillary netvvork. İt metastased with hemotagen pathvvay in early State ıt shows a poor prognosis. Fourty years old woman. Left breast mass and axillary lymphadenopathy presenced in physical examination. Biopsy was reported primer angiosarcoma of the breast. After the modified radical mastectomy, adjuvant chemotheraphy and radiotheraphy was performed. Patient was tost inpostoperative 12th month with lung and bone metastasis.

The work presents the clinical and cytogenetic findings in a 8 year-old female-patient with Turner phenotype and 46,X,del(X)(q22) karyotype. We discuss the difficulties of phenotype -karyotype correlation in cases with X chromosome structural aberation.