Selçuk Tıp Dergisi Arşiv

İn this study the antifungal susceptibility patterns of 63 clinical isolates of Candida albicans isolated from from hospitalized patiens vvere studied against amphotericin B, ketoconazole fluconazole and itraconazole using the Epsilometer test (E-test). Most of the isolates vvere isolated from urine samples (76.1%). The MIC ranges determined at 24 h incubation for amphotericin B, ketoconazole fluconazole and itraconazole vvere: <0.002-0.38. 0.004->32, 0.25->256, 0.008->32 respectively. The MIC50 and MIC90 (mg/l) for each antifungal vvere; amphotericin B 0.032, 0.125, ketoconazole 0.38, 4, fluconazole 2, 64 and itraconazole 0.094, 3. Ali strains vvere susceptible to amphotericin B, the resistance rates vvere 19.2% for fluconazole and 17.8% for itraconazole. Five İsolates shovved >32mg/l MIC values for ketoconazole. The results indicate that there is resistance against antifungal agents and this increases the importance of antifungal susceptibility tests.

İn this study, we evaluated urine samples of the patients who admitted to the microbiology laboratory of Selçuk University betvveen the years 1991 and January 2000. We determined the effective pathogens of urinary tract infections and their isolation rates. Totally 8901 (18.6%) effective pathogens were isolated from 47794 urine samples. Most freçuently isolated pathogens were E. coli (45.4%), S. aureus (11.4%) and Proteus spp. (10.2%).

İn this study the in vitro activities of twelve antimicrobial agents against 50 Salmonella and 25 Shigella strains isolated in the years 1999 and 2000 at the Microbiology Laboratory of the University of Selçuk Faculty of Medicine were investigated by E test method. Of the 50 Salmonella strains 30 were identified as S. thyphimurium and 20 as S.enteritidis. İn this study for Salmonella isolates resistance to ampicillin was most common (90%), follovved by tetracycline (64%), chloramphenicol (48%), trimethoprim/sulfamethoxazole (16%), cefuroxime (16%), cefodizime, ceftriaxone, ceftazidime and cefepime (6%). Ali isolates were susceptible to meropenem, imipenem and ciprofloxacin. For 25 shigella isolates of our study the resistance were 88% for ampicillin, 76% for tetracycline, 64% for trimethoprim/sulphamethoxazole, 28% for chloramphenicol, 12% for cefuroxime and 4% for ciprofloxacin. Ali Shigella isolates were sensitive against meropenem, imipenem, cefodizime, ceftriaxone, ceftazidime and cefepime.

Purpose: The aim of this study was to detect the effectiveness of mannitol’s antioxidant capacity in the treatment of ischemia-reperfusion injury after acute Peripherie arterial occlusion. Material and Methods: 20 healthy individuals and 32 patients with acute arterial occlusion were taken to study. Of the acute isehemia diagnosed patients, Standard surgery was performed on 17 patients and surgery and mannitol infusion were given to 15 patients. Blood samples were taken from the deep veins and MDA, CPK, GSH-PX levels were measured in the acute isehemia diagnosed period and 120th minutes of the reperfusion. Results: MDA of mannitol treatment group in the isehemie period meaningfully inereased in consideration with the control group. İn consideration of reperfusion period with isehemie group in mannitol treatment MDA signjficantly decreased. İn the reperfusion period of mannitol treatment GSH-PX significantly inereased according to control group. Although the CPK results showed significant inerease in each period of both treatments, the reperfusion period of mannitol treatment showed a significant decrease in CPK considering with it’s isehemie period. Conclusion: İn acute arterial occlusions it was shown that mannitol decreases the activity of free oxygen radicals, inereases the antioxidant capacity, and decreases the tissue injury meaningfully.

İn this study, we analysed 101 cases operated by the microsurgical technique for lumbar disc herniation betvveen 1997 and 2000 in Selçuk University Medical School Department of Neurosurgery. We have concluded, patients operated with microsurgical technique, undergo a shorter operation, discharged the hospital earlier, recover more quickly, and return to work earlier.

Infravesical obstruction as a result of acute üretral stricture was a common pathology in males and a rare pathology in female. İt developed secondary to infection and trauma. İt gain importance because by preventing urine flovv it produce upper urinary tract damage. İn our clinic a total of 243 patients with a mean age of 58 years have shown to have üretral stricture during last 10 years. We benifit from their physical examination, retrograde uretherografhy, IVP+postvoiding cystogram, ultrasonography and uretherography. İnternal urethrotomy was applied for 150 patients, bladder neck TUR for 36 patients, urethroplasty for 6 patients and rail-road urethroplasty for 3 patients. Four years of follovv up shovved recurrent urethral narrovving in 60% of patient internal urethrotomy, 6 montly dilatation in 75% of patients vvith urehral dilatation, recurrent narrovving in 10% of patients vvith bladder neck TUR and internal urethrotomi in 60% of patients vvith rail-road uretroplasty. Inspite of a new developed techniçues for urethral stricture it keep its recurrent, narrovving especialty which recquires continous follovv up.

A 8- mounth- old gir! was referred to our laboratory because of Down Syndrome. She had had phenotypical features as mild mental retardation, flated nasal bridge, low- set and malformed ears. İn detailed family history, her mother had had an carbon monoxide poisoning during proband’s pregnancy and an abortus before her. Chromosome analysis was carried on peripheral blood lymphocytes culture, using standart technigues and chromosomes were identified by using GTG, C and NOR- banding. Her karyotype was foundjo be 46, XX, t (4q;22q), inv(9). Family studies were shovved that neither her mother nor her father had carried this translocation but inv(9) was inherited from her mother to our patient. Our patient who seems as though a de novo balanced translocation carrier was discussed under the light of literatüre with her biochemical, radiologic and clinic features.

Spinal epidural abscess is a very rare and dangerous lesion. We present here spondylodiscitis case developed follovving iatrogenic spinal epidural abscess. The patient was operated on by surgical drainage and appropriate antibiotic therapy. Improvement was seen postoperatively. İn this article, the clinical outcome, radiological findings, and management prothocoles of spinal epidural abscess and spondylodiscitis are discussed with revievv of the literatüre.

Two patients have been operated tor pulmonary arteriovenous fistula at the Department of Thoracic Surgery, School of Medicine, University of Selçuk, Konya. The patients were adults, 49 and 62 years-old. Fistules were localized in the right lower lobe in first one and in the right upper lobe in second. The type of the operation was lobectomy in both cases. Among our patients with pulmonary arteriovenous fistulas, hereditary hemorrhagic telengiectasia was not observed. İn this article, the pathogenesis, clinical features, pathophysiologic changes, and treatment of pulmonary arteriovenous fistulas are discussed.

Purpose: After a few reports on end-to-side nerve repair at the beginning of this century, the technique was put aside until it has recently been reintroduced by Viterbo. VVe herein present the results of three cases treated by end-to-side median-to-ulnar neurorraphy. Methods: Three patients vvith median nerve defects betvveen 15 and 22cm were treated by end-to-side nerve repair, through an epineurial window. The follow-up times were betvveen 12 and 18 months. Sensory evaluation involved superficial touch, pin-prick, and two poi'nt discrimination tests. Motor evaluation was done by assessing the presence of opposition, and palpating the abductor pollicis brevis. Results: Sensory recovery was observed in ali the patients, in the median nerve dermatome. İn case-3 it was incomplete at the tips of his fingers. Motor recovery vvas absent, except in case-1, who could perform opposition before the operation, as well. Conclusions: End-to-side nerve repair is a viable alternative in cases vvith long gaps betvveen the ends of the injured nerve.

A successful partial left ventriculectomy and mitral valve replacement (Batista) operation with 31 No Sorin prosthetic valve performed to a 45 year old female patient for end-stage heart failure and dilated cardiomyopathy (class IV NYHA) which occured secondary to mitral valve disease and was resistant to ali medications. Postoperative control echocardiography revealed a 15-20% increase in the ejection fraction (with simps method) in comparison with preoperative echocardiography. The severe heart failure symptoms of the patient recovered and she is discharged in the 1&h d ay.