Selçuk Tıp Dergisi Arşiv

İn this study, the pregnant women live in Yenimahalle Training and Research Health Department (YMTRHD) region, at the 24-28 th pregnancy week were applied the Glucose Scanning Test in order to determine the abnor- mal glucose values. On June 2001 and in YMTRHD region, there has been 205 pregnant women at the midwives. 201 of them (98%) was accepted to fulfill the scanning test. The mean age of the pregnant vvomen was 26.9±5.5. İn the study we found the rate of positiveness in Glucose Scanning Test (GST) as 18.9%; and the rate of positive- ness in Oral Glucose Tolerance Test as 4.5%. İt is observed that GSTpositiveness has no relation with diabetes- existence, macrosomia story, obesity and parity (p>0.05). Consequently, Gst was determined positive in the 18.9% of the pregnant women who live in YMTRHD region. İt is observed that parity, aprevious history of overweight born baby, Body Mass lndex (BMI) and diabetes history in the family do not change the result of the test. For this rea- son, it has been determined that GST should be applied to ali the pregnant women who exceed 24th week of preg­ nancy.

Usually markers for proliferating cells need freshly frozen tissues for evaluation; therefore retrospective study is impossible. Proliferating celi nuclear antigen (PCNA) isapplicable to formalin-fixed, paraffin embedded tissues. İn this study, PCNA expression in cutaneous keratinous neoplasms were determined by immunohistochemical stain- ing using the 19A2 done. Sçuamous celi carcinoma (SCC) a unique expression of PCNA, which frequently involved the nuclei of ali keratinocytes vvithin the lesion was found. PCNA expression in verruca vulgaris (VV) and found a pattern similar to that in SCC. SCC and VV showed significantly increased numbers of PCNA positive cells when compared with other keratinocytic neoplasms.

İn this in vitro study, the effects of H2 O2 on bovine coronary artery and roles of K+ channels and cyclooxygenase, nitric oxide synthase and Na+/K+-ATPase enzymes for these effects were investigated. Strips from arteries were mounted in 25 mİ organ baths containing Krebs-Henseleit Solution at 37 °C aerated with %95 O2 and %5 CO2 . Effects of H2 O2 on basal tone of tissues with and without endothelium were investigated. İn the second part of study, tissues were contracted with U46619 (3x10~7 M) and H2 O2 (1Cr7-1(T2M) was added to the organ baths, cumulatively. This procedure was repeated on tissues incubated with apamin (10~6M), charybdotoxin (10-7M), tetraethylammonium (TEA, 1Ch4M), glibenclamide (10-6M), indomethacin (10~5M), NG-nitro-L-arginine methyl ester (L-NAME, 10~4M) and ouabaine (10~5 M). Each group of tissue was incubated with only one of these agents. H2 O2 did not affect basal tone of tissues with and without endothelium but relaxed tissues contracted with U46619in con- centration dependent manner. İn tissues with endothelium and in tissues incubated with apamine, charybdotoxine and tetraethylammonium, Emax values and plC50 values of H2 O2 were not different significantly from values obtained from tissues vvithout endothelium (control tissues). However values obtained from tissues incubated with glibenclamide, indomethacin, L-NAME and ouabaine were different significantly from values obtained from tissues without endothelium.These results indicate that ATP-sensitive potassium channels and cyclooxygenase, nitric oxide synthase and Na+/K+-ATPase enzymes play role in the relaxant effects of H2 O2 on bovine coronary artery smooth muscle.

Experimental studies showed that recurrent exposure to sevoflurane can be toxic. İt may be either related with direct effects of this anaesthetic agent or with the degradation of sevoflurane by soda lime which is also known to produce toxic products. The aim of this study was to investigate the effect of repeated sevoflurane anaesthesia on kidney and liver in rats vvith or vvithout soda lime. After local ethical comitte aproval thirty adult VVistar rats vvere divided into three groups. The rats were placed in a specially prepared transparant plastic box. Group C was the control group. Theyreceived 100% O2 . İn the anaesthesia circle vvithout soda-lime sevoflurane in 2.5 -2 .7 % concentration vvith O2 (100 %) were administered directly in group S, vvhile the same gas mixture was applied through the soda lime in group SS. Bepeated anesthesia (five times) was applied to the rats for sixty nainutes vvith two days intervals. Blodd ürea nitrogene, creatinin, SGOT, SGPT and ALP levels were assessed from the blood sample. Follovving sacrifice, kidneys and livers vvere obtained from the rats for examination using light microscopy for histopathological evaluation and mean damage scores (MDS) of the specimens vvere calculated. SGPT values were higherin group S and SS vvhen compared vvith group C (p<0.05). There vvere only minimal changes in histopathological evaluation of liver vvhich was not statistically significant. The changes in BUN and creatinin levels vvere not significant among the groups. The MDS’s in renal tissues vvere significantly higher in group S and SS vvhen compared vvith group C, vvhile there vvere no dif- ferences betvveen group S and SS. İt vvas concluded that repeated exposure to sevoflurane has minimal effects in liver accord- ing to mean damage score and in the presence of soda lime, sevoflurane anaesthesia vvith 100 % oxygene did not signifi­ cantly increased histopathological damage to liver. The toxic effects of sevoflurane on renal tissue vvere greater in rats espe- cially vvhen sevoflurane vvas administered through the sodalime

Neurophysiological studies have shown decreased excitability of the brain stem inhibitory interneurons in patients with headache. The C3 component of the trigemino-cervical reflex is nociceptive in character and may reflect the brain stem interneuron activity. This reflex is evoked by stimulation of the supraorbital nerve and recorded from the neck muscles. VVe recorded this reflex in 16 patients with migraine without aura and in 20 healthy subjects. There was not significant difference in latencies and amplitudes betvveen the two groups. VVe concluded that there is not decrease in brain stem inhibitory interneuronal activity İn migraine and this mechanism may not be responsible from pain control.

İn order to evaluate the role of C. pneumoniae infections in exacerbations of asthma in children and effects of clarithromycin therapy, 25 children with asthma exacerbation were enrolled in the study. Twenty-five sex and age matched children without any history of respiratory tract infection in last three months and atopy served as control group. Serum samples for the determination of C. pneumoniae spesific IgG and IgA antibody leves of C. pneu­ moniae were taken on admission with acute exacerbation and 4th and 12th weeks after exacerbation in asthmatic children. One serum sample was collected from Controls. Appropriate acute exacerbation therapy and clarithromycin 15 mg/kg body weight/day for 10 days were given ali asthmatic children. The prevalance of C. pneu­ moniae spesific IgG and IgA was similar in asthmatic children during acute exacerbation, at 4th and 12 th weeks after exacerbation and in Controls (p > 0.05). VVhen C. pneumoniae spesific antibody lndex values were evaluate in the asthmatic children after treatment, significantly decreases were detected in IgG levels (p<0.05). Our results suggest that C. pneumoniae infections is not an important cause of acute asthma exacerbations in children, however the antibody index values of IgG were significantly decreases with clarithromycin therapy.

Aim: The aim of this study was to compare the effects of direct trocar insertion and Veress needle insertion on complication ratio, CO2 volüme and time consumption during laparoscopic procedures. Materials and Methods: 152 patients were included in this study which vvere operated forcholelithiasis laparoscopically in Selçuk University Meram Medical Faculty betvveen January 1998 - January 2001. The patients vvere divided into tvvo groups ran- domly. Group I: pneumoperitoneum was performed with direct trocar insertion after general anaesthesia, Group II: pneumoperitoneum was performed with Veress needle and trocar vvas inserted after general anaesthesia. Complication ratios and, time consumption and CO2 volüme vvere calculated in tvvo groups. Findings: Copmlication ratios vvere 11.8% in Group I and 13.2% in Group II, and the differences vvere not significant. CO2 volüme used insufflation and insufflation time vvere significantly more in group II than in group I (p<0.001). Conclusion: Direct trocar insertion vvithout pneumoperitoneum vvas superior than Veress needle insertion vvith respect of CO2 volüme and time consumption.

Camptodactyly is a congenital flexion deformity of the proximal interphalangial joint in the anteroposterior plane. Many factors have been claimed for its etiology and, many alternatives have been proposed for treatment. Eleven patients with an average age of 21 were treated between 1993 and 2001 and included in this study. Ali the patients had bilateral camptodactyly in the fifth finger. After releasing the skin contracture by “Z” plasty, dynamic splint was applied for both fingers in extension for approximately 6 months. The mean follow-up time was 20 mounths and there were no recurrences in any patient. Our method of treatment has no surprises tike extensive surgical treat­ ment and has acceptable results in selected cases.

This is a group of Progressive renaldisorders that usualy have their onset in childhood. The common characteris- tic is the peresence of a variable number of cysts in the medulla associated with significant cortical tubular atro- phy and interstitial fibrosis. Although the presence of medullary cysts is important, the corticaltubulointerstitial dam- age is the causeof the eventual renal incufficiency. İt has four variants: 1- Sporodic, nonfamilial (% 20); 2- Familial juvenile nephronophytisis (% 50), inherited asa recessive disease; 3- Renal - retinal dysplasia (% 15), recessively inherited and associated with retinitis pigmentosa; and 4-Adult onset medullary cystic disease, dominantly inherited (%15). The case had shown the view of sporadic nonfamilial variant of UMCD and was presented because of the rarity in literatüre it.

Esophageal achalasia in childhood especially in whom below one year of age is a rare lesion and difficult to diag- nose. An 11 months age female infant has been treated successfully by pneumatic dilatation, after returning of the esophagus to it’s normal calibre there was no complications seen in the barium study that performed later. After a follow up period of 12 months there was no vomiting or feeding problems or recurrence of the achalasia.

Surgical correction of an aesthetic deficit causing, a psychological problem, is routinely performed. On the other hand, if a complaint that can not be regarded as an aesthetic deficit, causes psychological, or even pathological changes, it is unfamiliar. İn this report we present a patient who has tied her hair tightly in order to lift her eyebrows and has caused tractional alopecia.

An 11 - year old boy presented to the emergency room with severe dyspnea and left upper chest pain. The initial chest radiograph showed a massive left pleural effusion, opacities in the left hemithorax and lytic areas in the left 3rd rib. A thoracocentesis demonstrated a hemothorax. Despite treatment with blood tansfusions and aspiration of hemothorax, the patient’s clinical status worsened and developed dyspnea. A thoracic computed tomograghic scan demonstrated a mass in the intrathoracic extrapulmonary space and a lytic lesion in the 3rd rib. A posterolateral thoracotomy was performed. Base on histologic findings, evving’s sarcoma vvas diagnosed. He was asymptomatic throughout the 11 months follovv - up. İntrathoracic extrapulmonary thoracic Evving’s sarcoma with spontaneous hemothroax is extremelyare.