Selçuk Tıp Dergisi Arşiv

In this study the toxic effects of formaldehyde to lungs and protective effects of omega-3 fatty acids against these toxic effects were investigated at histological and biochemical levels. For this purpose, 21 adult male Wistar rats were divided into three groups. Rats in group I were used as control. Rats in group II were injected with formaldehyde every other day. Rats in group III Daily received omega-3 fatty acids with injection of formaldehyde. At the end of 14 days experimental period all rats were killed by decapitation. The lung tissue specimens which were taken from the rats were examined under light microscope after performing the routine histological procedures. The activities of superoxide dismutase (SOD), catalase (CAT), xanthine oxidase (XO) and malondialdehyde (MDA) were determined in the lung specimens by using spectrophotometric methods. In our study in rats whom formaldehyde was given a statistically significant increase in the levels of SOD, XO and MDA was determined when compared to control group. A significant decrease in the level of CAT was also detected. In the light microscopic examination of this group, bleeding areas in interstitium, hemosiderin loaded macrophages and ephitelial spilths on terminal bronchiales was observed. It was determined that the histological variances which caused by formaldehyde exposure were decreased in ratswhom received omega-3 fatty acids along with formeldehyde. In addition a decrease in SOD, XO, MDA levels and an increase of CAT levels were determined. Asa result, it was determined that damage accured in lung tissue of rats exposured to formaldehyde and this damage was prevented by the application of omega-3 fatty acids.

Fort he assesment of the suitable therapy and prognosis; some histopathological features especially determining axillary lymph nodes correctly becomes so much important. Between the years 1998 and 2001 at Selcuk University Meram Medical Faculty pathology Laboratory 777 axillary Iymph nodes materials obtained from 47 modified mastectomy examined retrospectively for determining the micrometastasis that couldn’t be found before. After serial sections in 2 of 19 cases micrometastasis were found. These 19 patient were said not to have metastasis before. The incidence of finding micrometastasis decreased as the serial section counts increased. As a result; serial section method is more effective than routine examinations for determining the micrometastasis and in the examinations using 20µ section interval and taking 6 sections is a recommendable method.

Fifty patients with atopic dermatitis and 25 healthy controls were enrolled in this study. Prick and patch tests were applied. Serum IgE and eosinophilia levels were measured, Relationship between IgE, eosinophilia and prick-patch test was investigated. Prick and patch tests were positivite in 27 (54%) and 22 (44%) respectively. Serum total IgE levels were elevated in 28 patients (56%) and eosinophilia was found in 9 patients (18%). Total IgE levels were elevated in 70.4 % and eosinophilia was found in 29 % of prick positivite patients. 50 % of patch positivite patients had elevated serum total IgE levels. Eosinophilia was found in 13.6 % of them. There was a statistically significant difference in the results of patch test between study and control groups (P=0.032). Prick, patch test and elevated serum total IgE levels were found in 36 %, 16 %, 4% in the control group, respectively. Eosinophilia was not seen. When total IgE and eosinophilia levels in the study and control group were compared, statistically significant relation was found (P=0.000) (P=0.025).

Quantitative assessment of ventricular function in patients with congenital heart disease is often challenging due to distorted ventricular geometry. A myocardial performance index (MPI) has been reported in adults and children that is a Doppler-derived non-geometric measure of ventricular function. The MPI measures the ratio of isovolumic time intervals to ventricular ejection time. The effects of altered ventricular preload or afterload on the MPI have yet to be determined. This study was designed to determine the impact of altered preload on left and right ventricular MPI nin the clinical setting of atrial septal defect (ASD). The left and right ventricular MPI were measured in 17 patients with ASD (ages 6 to 148 months, median 24 months) and 24 normal children (ages 3 to 160 months, median 17 months). In patients with ASD and control groups, the left ventricular MPI was 0.38±0.16 and 0.32±0.09 and the right ventricular MPI was 0.24±0.15 and 0.20±0.08 respectively. No significant change in the left and right ventricular MPI was seen in patients with atrial septal defect and control groups. This study documents that the MPI is a quantitative measure of ventricular function that is appears to be relatively independent of changes in preload.

In pürine pathway, adenosine deaminase is a cytoplasmic enzyme which changes adenosine into inosine and ammoniumi deoxyadenosine into deoxyinosine and ammonium catalyzed irreversibly. Activation of ADA in human fluids is by two enzymes: ADA1 and ADA2. Increased ADA levels in tuberculosis pleural effusion have %81-100 sensivity and %83-100 specivity. ADA in tuberculosis effusions originated from macrophages and monosit is mainly ADA2. ADA level also can be increased in ampiyem, lenfoproliteratif disorders and parapnömonic pleural effusions which have ıymphocyte cell mostly.

At times, pleural fluid is milky or turbid. When the milkiness or turbidity persists after cetrifugation it is almost always due to high lipid content of the pleural. High levels of lipid accumulate in the pleural fluid in two situations: Chylous and chyliform pleural effusions. It is important to differentiate these two conditions because the prognosis and management are completely different. The most common causes of the nontraumatic chylothorax are malignancies. We report a 60 year old female patient diagnosis of non-Hodgkin’s Iymphoma with huge mediastinal Iymphadenopathies and bilateral chylothorax. We treated her with chemoterapy.

Marjolin’s ulcer is a term to describe a malignancy arising from scar tissue, especially burn scars. It appears on burn scar a long period after initial burn injury. The most common malignancy is squamous cell carcinoma (SCC) for these type of patients. Basal cell carcinoma, melanoma and sarcoma have less frequently been reported. Biopsy is the most important diagnostic procedure. The treatment is wide excision and regional lymph node dissection. A 12 year old child admitted to our clinic with unhealed wound in the axillary region for ten months. The patient had an ulcer axillary region through thorax. Incisional biopsy was performed. Histopathologic examination revealed that SCC. Wide surgical excision was done. The defect area was covered with flap. Axillar contracture was reconstructed with Z-platies. The case was presented due to early development of Marjolin’s ulcer as in ten years.