Selçuk Tıp Dergisi Arşiv

It was reported previously that serum total sialic acid levels were increased in various cancers including breast cancer. We aimed to evaluate the effect of aromatase inhibitor therapy on serum total sialic acid levels in breast cancer patients. Total sialic acid levels were determined in sera of 20 patients with breast cancer and treated with aromatase inhibitors. Total sialic acid levels were determined by a colorimetric method. Serum total sialic acid levels were 15,06±2,71 mmol/ml and 8,17±5,31 mmol/ml at the beginning and three months after the treatment respectively. Thus, a significant decrease in total sialic acid levels was observed after the treatment (p

A single dose spinal analgesia (SDSA) has been defined as an alternative method for the cases which are late for epidural labour analgesia. This study was undertaken to present our experiences on SDSA for multiparous parturients who attended to the obstetrical ward during the advanced stages of labour and requested analgesia. The files of 48 multiparous parturients who applied for SDSA method for labor analgesia between 1 January and 30 July 2009 were retrospectively analyzed. SDSA was performed with 2.5mg levobupivacaine combined with 15µg fentanyl, and 1.2 ml normal saline, using a 27 G pencil point needle in the sitting position. Initiation time of analgesic effect, duration of the second stage of labour lasting after application of SDSA, the number of parturients who needed rescue analgesic and side effects were recorded. SDSA was successfully performed in all parturients. The mean initiation time of analgesic effect and the second stage of labour lasting after application of SDSA were 2.6±0.7/min and 62.2±20 / min, respectively. Six parturients (12.5%) needed rescue analgesic. No side effects were observed except pruritus which occurred in 15 (31%) parturients. The method of SDSA was sufficient in 87.5% of multiparous parturient who requested labour analgesia at the advanced stages of labour. Further studies that include alternative combination of easy and effective methods are needed to increase the success rate of this method.

A retrospective study was performed to investigate the mortality among the patients hospitalized in department of chest diseases Dicle University medical school clinic. The patients passed out in this clinic in the period from January 2004 to May 2009 were evaluated. It was determined that totally 4417 patients were hospitalized (8892 hospitalization) in this period and 384 (8.6%) of them resulted in death. The mean age of the patients was 66.8±15.3 and 92 (33%) were women and 187 (67%) were men. The principal causes of their mortality were pneumonia in 92 patients (33.1%), chronic obstructive pulmonary disease (COPD) in 87 (31.2%) patients, pulmonary cancer in 52 (18.6%) patients, tuberculosis (TB) in 18 (6.5%) patients, pulmonary thromboembolism (PE) in 18 (6.5%) patients and another diseases in 12 (4,2%). When the accompanying diseases were evaluated, no additional diseases were determined in 130 (46.6%) patients; 41 patients (14.7%) had cardiac disorders, 22 patients (7.9%) had cancers outside the lungs, 18 patients (6.5%) had cor pulmonale, 17 patients (6.1%) had neurologic disorders, 15 patients (5.4%) had renal diseases, 10 patients (3.6%) had diabetes mellitus (DM), 9 patients (3.1%) had TB and 17 patients (6.1) had unclassified disorders. In conclusion, we think that the knowledge about their mortality rates and the causes of mortality is useful for every clinic for their approach to the patients and considering the accompanying diseases is helpful to decrease the mortality

The evaluation of patients who had myomectomy performed during caesarean section in our clinic. The data of 44 patients who had myomectomy performed during caesarean section in our clinic between June 2006 and January 2010 were analyzed retrospectively. Data regarding patient age, gravidity, abortions, gestational age, indication for caesarean section, the position and size of fibroids detected during caesarean section, hemoglobin value before and after the operation and the difference between the two values, intraoperative hemorrhage, need for blood transfusion, duration of the operation, days of hospitalization and the results of histopathological examination of myomectomy materials. The average age of patients was 33.3±4.9 (25-44) and average gestational age was 37.5±2.3 (28-41) weeks. The average size of the fibroids was 6.61±2.7 cm (3-18 cm). Subserous myoms were the most frequently seen ones with fundal or corporal localization in most of the instances. The preoperative and post-operative values of hemoglobin were 11.9±0.9 g/ dL and 10.2±1.1 g/dL respectively and the difference was statistically significant (p

Although microsurgery has rapid advanced, problems at the site of venous microanastomosis still continue. Thrombosis of the venous microanastomosis is the major reason for free tissue transfer and replantation complications. Erythropoietin is a principal hematopoietic regulator responsible for the proliferation and diferentiation of erythroid progenitor cells and endothelial cells. Aim of this study is to observe the complications of microvenous anastomosis line and to investigate the protective effects of erythropoietin. Seventy eight Sprague-Dawley rats were divided into two groups (Control and Erythropoietin), and the groups were subdivided into three groups (3rd, 5th and 7th days). Rat dorsal penil vein was the study model. One-hundred-fifty IU/kg Erythropoietin was administrated via subcutaneously instantly venous anastomosis and every 48 hours to all Erythropoietin groups. Penil vein anastomosis line samples and blood samples were taken for assesment at 3rd, 5th and 7th days, after venous anastomosis. Morphometric analysis of each venous segment was done with a Clemex analysis program by the same examiner. Neointimal and medial areas were measured in each section and the neointima/media ratio was calculated. Haematocrit values were measured in all rats for 3rd, 5th and 7th days. The ratio of intima to medial areas were significantly less in Erythropoietin groups for 3rd and 5th days compared to control groups for the same days. There were no significant difference for the ratio of intima to medial areas between the contol and erythropoietin groups for 7th day. There were no significant difference for haematocrit levels between the the control and erythropoietin groups at 3rd, 5th and 7th days. Our study has shown that erythropoietin administration markedly reduced intimal formation and risk of thrombosis with accelerated endothelial regeneration after microvascular anastomosis in rat dorsal penil vein.

The diagnosis and the early treatment of the thyroid diseases occuring before and during pregnancy are essential for both mother and baby. Increased synthesis of the thyroid hormones, urinary iodine loss, and transfer of iodine to the fetus through the placenta increase the daily iodine requirement in pregnant women. In order to evaluate the thyroid functions in pregnant women, the serum free T4 (fT4), free T3 (fT3), and TSH levels should be determined. Low levels of maternal and fetal thyroxin, lead to irreversible central nervous system development defects, where endemic cretinism and mental retardation are the most significant complications. Therefore, if possible, iodine treatment should be initiated prior to pregnancy. On the other hand hyperthyroidism, can lead to complications such as abortion, premature birth, preeclampsia, and placenta detachment. Thus, thyroid function tests should be monitored carefully during pregnancy

Tuberculosis is a disease that can mostly be diagnosed, and may involve all organs; however also may frequently mimic other disease of the involved organs and sometimes causes diagnostic problems. In our case we presented a patient that we thought to be lung cancer, however diagnosed as tuberculosis after the evaluations. We think that in countries with high tuberculosis incidence and prevalence such as our country, tuberculosis should be kept in mind in differential diagnosis in every clinical and radiological feature.

Brucellosis is a zoonotic disease caused by bacteria of the Brucella subspecies from the gram-negative bacteria family. Brucellosis continues to be a public health problem worldwide, especially in developing countries. The bacteria can involve the reticuloendothelial system foremost, and many systems such as joints, the heart and the kidneys. Despite the respiratory system involvement being known, lung involvement is rare. Non-specific findings and complications in the patients with lung involvement makes the diagnosis difficult. In this case report, a 6-year-old male patient, presenting with the complaints of fever, cough, expectoration, hemoptysis, exhaustion, anorexia and knee ache, was hospitalized with the diagnosis of pneumonia and pleural effusion. On the performed examinations, hepatosplenomegaly and bicytopenia were detected. The Rose-Bengal test was (+++) and the Wright agglutination test was 1/1280 (+) in the blood and pleural effusion fluids of the case. The case was considered to be a pneumonia and pleural effusion due to brucella. The case has been presented since it is rarely seen, and in order to emphasize that in countries such as ours, in which brucella is endemic, complications due to brucella show a wide spectrum.

Uraemia is a syndrome of clinical and metabolic abnormalities that develop in parallel with deteriorating renal function. The neurological consequences of uraemia are similar in many ways to the central nervous system effects of other metabolic and toxic disorders. There are several recent case reports of acute movement disorders with bilateral basal ganglia involvement in diabetic uraemic patients. We studied MRI and DWI findings of a patient with diabetus mellitus and chronic renal failure who developed acute ensepholopathy. Patients with diabetes mellitus and chronic renal failure may be progress to acute ensepholopathy. After hemodialysis semptoms are regressed; MRI can be used succesfully at acute phase and after hemodialysis.