Makale Arama

Psoriasis and vitiligo are relatively frequent dermatoses in dermatology practice. Although there are a lot of case reports about patients having both psoriasis and vitiligo, there have been few published case reports about development of vitiligo on lesions of psoriasis vulgaris and also it is a very uncommon clinical situation during psoriasis treatment. Here, we report development of vitiligo on only healed psoriasis plaques in 45-year-old man treated with cyclosporine for psoriasis.

The aim of this study was to evaluate the frequency and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis (Ps). One hundred and four patients who are following with psoriasis in Dermatology outpatients were included. The patients were examined for PsA according to Classification criteria for psoriatic arthritis (CASPAR). Psoriatic arthritis was determined in 10 (% 9.6) patients. The first presenting symptom was skin lesion in five patients. The most common type of skin lesion was plaque Ps both Ps and PsA. Peripheric joint involvement was detected in 9 patients. The most common manifestation pattern is oligoarthritis (4 patients), followed by polyarthritis (3 patients), spondyloarthropathy (2 patients) and distal interphalangeal (DIP) arthritis (1 patient). The psoriasis area and severity index (PASI) was observed similarly in patients with PsA (4.92±5.3) and those without PsA (4.87±3.3). Nail involvement was significantly more common in patients with PsA (%100) than those without PsA (%53.2). As a result; the frequency of PsA in patients with Ps was found as % 9.6. Nail involvement was observed in all patients with PsA.

Aim: Bullous pemphigoid (BP) is a bullous dermatosis frequently seen in advanced age that is caused by antibodies reacting to antigens in the dermoepidermal junction. It has been reported that as a result of autoantibody-induced inflammation, inflammatory mediators are increased in patient sera and bullae, and that these increased mediators might be related to disease severity. Neutrophil lymphocyte ratio (NLR) is determined by dividing the number of neutrophils by the number of lymphocytes; it is a parameter that has been previously studied in inflammatory diseases such as urticaria, psoriasis, pemphigus vulgaris and cutaneous vasculitis and has been associated with the disease. The present study investigated the utility of NLR, the marker of systemic inflammation, as a marker in patients with BP. Patients and Methods: Medical records of patients diagnosed with BP between January 2013 and December 2017 were reviewed. By evaluating the laboratory results in their files, the mean platelet volume (MPV), neutrophil count, lymphocyte count, and neutrophil lymphocyte ratio calculated by dividing the number of neutrophils by the number of lymphocytes were recorded. Results: The study included 26 patients with BP and 25 control patients. Neutrophil count (P = 0.005) and NLR (P = 0.04) were found to be higher in patients with BP compared with the control group. No difference was found in lymphocyte count and MPV between the groups. Conclusion: To our knowledge, this is the first study to investigate NLR in patients with BP in the etiopathogenesis of which inflammation takes a part. We believe that NLR, a parameter that can be easily calculated by a whole blood count for systemic inflammation, can be a marker that can be used in the diagnosis of BP.

It has been reported different results about the prevalence of Helicobacter pylori infection in patients with psoriasis. In several studies, although the prevalence of Helicobacter pylori was reported to be increased, in some studies it could not be shown same results. In this study, we aimed to evaluate the prevalence of Helicobacter pylori infection and the association between disease activity and infection in patients with psoriasis. A total of 11 (8 male, 3 female) patients with psoriasis and 23 healthy controls (18 male, 5 female) were included in the study. Helicobacter pylori infection was diagnosed with biopsy which was obtained from the antrum and the body of stomach or with urea breath test. Before and after Helicobacter pylori eradication, disease activity was revealed with psoriasis area severity index. Sequential eradication regimen was preferred treatment for helicobacter pylori. Urea breath test was used to evaluate the eradication after the treatment Nine (% 82) of 11 patients with psoriasis had positivity for Helicobacter pylori while 11 subjects (% 47,8) of 23 had positivity for Helicobacter pylori in the control group. After the eradication treatment, Helicobacter pylori were negative in six patients. Four patients returned for follow-up visits and psoriasis area severity index had significantly resolved in only one of them. In conclusion, however the number of patients is so not much, in this study the prevalence of Helicobacter pylori was observed to be more frequent in patients with psoriasis but no association between disease activity and infection was found. Further studies are needed to show the association between disease activity and Helicobacter pylori infection.

Aim: The relationship between age of onset, family history, extent of disease and serum prolactin levels of psoriasis patients were investigated. Material and method: Seventyfive psoriatic patients were enrolled for the study and 40 healthy volunteer were taken as control group. Age, sex and serum prolactin levels of the patients were recorded. The patients were questioned for family history and age of onset of psoriasis. The type, extent of psoriasis and whether the patient had artrit or not were recorded. Results: Twentytwo (29.3%) out of 75 patients with psoriasis, one patient (2.5%) in the control group had positive family history. When compared with non psoriatic patients, there was a statistically significant difference at the risk of seeing psoriasis in psoriatic patient’s other family members. Forty nine (65.3%) out of 75 psoriatic patients had early onset, 26 (34.7%) had late onset psoriasis. 21 (42.9%) of the patients with early onset psoriasis and 1 (3.8%) of the patients with late onset psoriasis had positive family histories. Fourteen (66.7%) out of 21 patients with early onset familial psoriasis had extensive disease, whereas 7 (25.0%) out of 28 patients with early onset sporadic psoriasis had extensive disease. When compared with patients who had early onset sporadic psoriasis, patients with early onset familial psoriasis had a higher risk of having extensive disease. High prolactin levels were detected only in 3 female patients in the psoriatic group. All of the patients in the control group had normal serum prolactin levels. Conclusion: There was not a statistically significant difference at serum prolactin levels when sex matched pairs of control and psoriasis group were compared.

In the study, in psorialic cutaneous tissues of 15 pallent ıvith psoriasis and in the healthy tissues of 20 control group zinc ion has been determined. Zinc ion in the control group was 1 .04±0.68 pgıg and Zn.2.49±1.02 1.41g at patients group as wet lissuc. Zinc ionfound to be greater (p<0.001) in psoriat-le iissue us compared with the ratio healthy tissue.

Psoriasis is chronic and inflainatory diseases which characterised with epidermal cell pro-liferation. There is a common. opinion about etiology of psoriasis which is explained with faulty im-munological respons of cells. It is emphasised that impaired T cell function is responsible of pathogenesis of the diseases. It has known. that cyclosporin-A is im-munsupresif and has selective efficacy on ke-ratinocysts and chronic intlamatory cells. By this re-ason in recent years it has begun to use cyclosporin-A, more frequently to cure psoriatic patients.